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6th Grade Science Common Core

Life Science

Free 6th grade life science worksheets. Free printable life science worksheets for 6th grade. Nine weeks covering cells and organelles, body systems, animal behavior and reproduction, genetic and environmental growth factors, and ecosystems — aligned to NGSS MS-LS1 and MS-LS2.

MS-LS1-1

What's Included

  • 5 worksheets per week
  • Full answer keys included
  • NGSS aligned (MS-LS1, MS-LS2)
  • Print-ready PDF format

All Weeks

Week 1

Life Science

Week 2

Life Science

Week 3

Life Science

Week 4

Life Science

Week 5

Life Science

Week 6

Life Science

Week 7

Life Science

Week 8

Life Science

Week 9

Life Science

About Life Science

Sixth grade life science covers a lot of ground, and the jump from elementary school science can catch kids off guard. Suddenly they’re expected to understand cell organelles, trace molecules through body systems, and argue with evidence about why ecosystems change. It’s real science with real vocabulary, and the kids who struggle usually aren’t lacking intelligence — they just haven’t had enough structured practice connecting the concepts.

This nine-week program builds that understanding from the ground up, starting with cells and working outward to ecosystems. Every worksheet uses the same approach: teach the concept first, then practice it with increasingly complex questions that move through Bloom’s taxonomy from remembering facts to evaluating evidence and constructing arguments.

Cells and How They Work

Weeks 1 and 2 start where all biology starts — with cells. Week 1 covers what cells are, why they’re the basic unit of life, and how plant cells differ from animal cells. Your child will learn the parts common to all cells (membrane, cytoplasm, nucleus) and the extras that plant cells carry (cell wall, chloroplasts, central vacuole). Week 2 goes deeper into organelles as a system: mitochondria producing energy, ribosomes building proteins, the ER processing them, the Golgi shipping them. The big idea isn’t memorizing parts — it’s understanding that a cell is a coordinated machine where every piece depends on the others.

Body Systems as Interacting Subsystems

Weeks 3 and 4 zoom out from cells to body systems and how they interact. Week 3 covers the digestive and respiratory systems — how food becomes glucose and how air becomes oxygen. The worksheets trace molecules from mouth to mitochondria, connecting what kids learned about cells to how the whole body works. Week 4 adds the circulatory and nervous systems, completing the picture: blood connects everything, and the nervous system coordinates it all. By the end of Week 4, your child should be able to argue with evidence that the body is a system of systems.

Animal Behavior and Growth

Week 5 tackles animal behavior and reproduction — mating displays, parental care, territorial behavior, and group living. Kids learn that these seemingly random behaviors evolved because they increase the probability of surviving offspring. The peacock’s ridiculous tail makes evolutionary sense once you understand honest signaling.

Week 6 covers how genetic and environmental factors interact to influence growth. This is the “nature AND nurture” week — genes set the potential, the environment determines how much of that potential gets realized. Identical plants in different soil, identical twins with different nutrition, Great Danes versus Chihuahuas in the same household. The examples make the concept concrete.

Ecosystems and How They Change

Weeks 7 and 8 move to ecosystems. Week 7 covers resource availability, carrying capacity, food webs, competition, predator-prey cycles, and symbiosis. Week 8 brings it together with ecosystem changes — how physical disruptions (drought, temperature shifts) and biological disruptions (invasive species, keystone species removal) cascade through entire communities. The Yellowstone wolf reintroduction, the brown tree snakes of Guam, the sea otter-urchin-kelp story — these aren’t just interesting anecdotes, they’re evidence for how interconnected ecosystems really are.

Week 9 is a comprehensive review that ties all the threads together: cells form systems, systems form organisms, organisms form ecosystems, and changes at any level ripple through the whole picture.

Every worksheet includes detailed answer keys so parents can check work and guide discussions, even without a science background.